| 51 |  VisItVisIt - Visualization and Data Analysis for Mesh-based Scientific Data | 3.4.2 | Open source | April 5, 2025 | — | ★ 537 |
| 52 |  XaoSReal-time interactive fractal zoomer | 4.3.4 | Open source | May 28, 2026 | — | ★ 627 |
| 53 |  QElectroTechA free and open-source application to create electrical diagrams | 0.100.0 | Open source | March 27, 2026 | — | ★ 587 |
| 54 |  ParsifyExtendable calculator for the 21st Century ⚡ | 2.0.1 | Open source | January 24, 2024 | — | ★ 237 |
| 55 |  kalkkalk is a powerful command line calculator app for developers. | 0.13.0 | Open source | September 21, 2025 | — | ★ 344 |
| 56 |  UGENEUGENE is a free open-source bioinformatics software for Windows, macOS, and Linux. | 53.1 | Open source | August 27, 2026 | — | ★ 284 |
| 57 |  TrackerVideo Analysis and Modeling Tool | 6.3.4 | Open source | March 31, 2026 | — | ★ 320 |
| 58 |  Avogadro2Avogadro is an advanced molecule editor and visualizer designed for cross-platform use in computational chemistry, molecular modeling, bioinformatics, materials science, and related areas. | 2.1.0 | Open source | October 26, 2026 | — | ★ 271 |
| 59 |  MCX StudioMonte Carlo eXtreme (MCX) - Physically accurate and validated GPU ray-tracer | v2025.10.20 | Open source | October 23, 2025 | 34.5 MB | ★ 195 |
| 60 |  Circuit DiagramDesign and share circuit diagrams using a wide range of components. | 3.1 | Open source | March 30, 2021 | — | ★ 316 |
| 61 |  HilbertAn offline desktop editor for Typst, aimed at maths and physics writing. | 0.2.9 | Open source | October 26, 2026 | — | ★ 144 |
| 62 |  WabbitemuA Z80 TI Calculator emulator | 1.9.5.22 | Open source | May 23, 2023 | — | ★ 335 |
| 63 |  BERT TookitBasic Excel R Toolkit | 2.4.4 | Open source | July 14, 2025 | — | ★ 208 |
| 64 |  FAIRshareSimplifying data curation for researchers working on COVID-19 research | 2.1.0 | Open source | March 20, 2024 | — | ★ 80 |
| 65 |  DataWarriorAn Open-Source Program for Data Visualization and Analysis with Chemical Intelligence | 6.1.0 | Open source | May 14, 2025 | 170.3 MB | ★ 168 |
| 66 |  NumeRe - Framework for Numerical ComputationsSolving and visualizing. Table based. Statistics and numerics. Optimized for science. Free of charge. GNU GPL v3. | 1.1.8.2609 | Open source | September 16, 2026 | — | ★ 31 |
| 67 |  NumeRe - Framework for Numerical Computations (Portable)Solving and visualizing. Table based. Statistics and numerics. Optimized for science. Free of charge. GNU GPL v3. | 1.1.8.2609 | Open source | September 16, 2026 | — | ★ 31 |
| 68 |  LaminaMath on a Sheet of Glass, Extended with User-Made Scripties. A WinUI 3 Calculator for Windows 11! | 11.28000.19.0 | Open source | October 3, 2026 | — | ★ 21 |
| 69 |  QSapecNG - Qt-based GUI for SapecNGQSapecNG is a Qt-based program for symbolic analysis of linear analog circuits. | 2.0.0 | Open source | November 11, 2024 | — | ★ 15 |
| 70 |  L'MathL'Math is software that allows you to create, store and test familiar formulas from Digab. Train for YO exams even while doing course assignments! | 1.10.15 | Other licence | August 18, 2025 | — | ★ 3 |
| 71 |  Bandwidth CalculatorA Windows calculator for determining download times and bandwidth requirements, quickly and accurately. | 1.2.0 | Open source | January 16, 2026 | — | ★ 2 |
| 72 | RR for WindowsR is a free software environment for statistical computing and graphics. | 4.6.1 | Open source | June 27, 2026 | 91.7 MB | — |
| 73 |  QCalcA multi-purpose calculator for productivity and accessibility | 0.13.2 | Open source | October 8, 2026 | — | ★ 3 |
| 74 | KKStars Desktop PlanetariumThe most feature-rich free astronomy software | 3.8.5 | Open source | October 3, 2026 | — | — |
| 75 |  TypeSymbolSystem-wide math shorthand daemon | 0.1.9 | Open source | April 25, 2026 | — | ★ 2 |
| 76 | MMathType 7Easily write math equations from anywhere | 7.12.3 | Proprietary | September 23, 2026 | 46.7 MB | — |
| 77 | SSnapGenePlan, visualize, & document core molecular biology procedures | 8.2.3 | Proprietary | August 25, 2026 | 150.4 MB | — |
| 78 | NNanomeAI assisted scientific copilot + multi-user spatial computing to accelerate scientific discovery drug discovery. | 2.7.1 | Proprietary | October 20, 2026 | 113.2 MB | — |
| 79 | GGeoGebra CAS CalculatorSolve equations, expand and factor expressions, find derivatives and integrals | 6.0.933 | Proprietary | October 19, 2026 | — | — |
| 80 | GGeoGebra Calculator SuiteExplore functions, solve equations, construct geometric shapes and 3D objects | 6.0.933 | Proprietary | October 19, 2026 | — | — |
| 81 | HHP Prime Virtual CalculatorA simulator of the HP Prime Graphing Calculator for Windows. | 2.4.2 | Free | September 9, 2026 | 85.4 MB | — |
| 82 | HHP Connectivity KitWindows-based software for connecting to the HP Prime calculator. | 2.4.2 | Free | September 19, 2026 | 73.2 MB | — |
| 83 | SSMath Studio EnterpriseTiny, but powerful mathematical program with WYSIWYG editor and complete units of measurements support. | 1.5.0-9678 | Proprietary | July 1, 2026 | 3.5 MB | — |
| 84 | TTI-Nspire CX CAS Student SoftwarePowerful computer software with a Computer Algebra System (CAS) that satisfies math and science curriculum needs from middle school through college. | 6.3.0.119 | Proprietary | August 25, 2025 | 220.7 MB | — |
| 85 | TTI-Nspire CX Premium Teacher SoftwarePresent concepts, encourage discussion and assess understanding with software that turns a teacher’s PC or Mac into a virtual TI-Nspire™ CX II graphing calculator. | 6.4.0.74 | Proprietary | February 5, 2026 | 454.6 MB | — |
| 86 | TTI-Nspire CX Student SoftwarePowerful computer software that satisfies math and science curriculum needs from middle school through college. | 6.3.0.119 | Proprietary | August 26, 2025 | 232.3 MB | — |
| 87 |  Beulea's Eve IndustryManufacturing cost & profit calculator for EVE Online — T1/T2 invention, T3, reactions, sourcing, multi-character industry planning. | 0.2.10 | Free | August 1, 2026 | — | — |
| 88 | SSaturn PCB ToolkitFreeware PCB design and engineering calculator suite | 8.48 | Free | October 14, 2026 | 17.9 MB | — |
| 89 | TTI-SmartView CE for the TI-84 Plus FamilyThe TI-SmartView™ CE software allows you to display a TI graphing calculator for your entire classroom. | 6.0.4.688 | Proprietary | July 7, 2026 | 399.9 MB | — |
| 90 |  InterpKitCLI tool for d/L0 to d/L function table lookup and interpolation | 2.0.0 | Open source | May 10, 2026 | — | — |
| 91 | GGpredictA real-time satellite tracking and orbit prediction application. | 2.3.37 | Open source | October 22, 2025 | — | — |
| 92 | AAxMathA Professional Formula Editor & Calculator | 2.7061 | Proprietary | October 1, 2024 | 13.4 MB | — |
| 93 | EENERCALCStructural Engineering Software | 20.26.10.15 | Proprietary | October 15, 2026 | 403.6 MB | — |
| 94 | EESBCalcFreeware Calculator | 7.3.1.0 | Free | February 3, 2025 | 1.3 MB | — |
| 95 | EESBCalc Pro TRIALScientific Calculator | 10.4.1.0 | Proprietary | February 3, 2025 | 4.4 MB | — |
| 96 | EESBDateCalc Pro TRIALDate Calculator for Windows | 10.2.0.0 | Proprietary | February 3, 2025 | 6.5 MB | — |
| 97 | FFreeMatFreeMat is a free environment for rapid engineering and scientific prototyping and data processing. It is similar to commercial systems such as MATLAB from Mathworks, and IDL from Research Systems, but is Open Source. | 4.2 | Open source | March 30, 2021 | 56.4 MB | — |
| 98 | KKStars Desktop Planetarium (AppX)A freely licenced, open source Astronomy Software by KDE. | 0.0.9438.0 | Open source | February 2, 2026 | — | — |
| 99 | LLabPlot2 (AppX)A free, open source spreadsheet, data visualisation, and analysis software accessible to everyone. | 2.1201.10343.0 | Open source | February 20, 2026 | — | — |
| 100 |  OmniculatorA command-line calculator for exact arithmetic, algebra, equation solving and calculus. | 0.5.3 | Open source | October 13, 2026 | — | — |