UGENE is a free open-source bioinformatics software for Windows, macOS, and Linux.
Publisher’s description
What is UGENE?
UGENE is an open-source science & math program for Windows from Unipro. It is written in C++.
Installation and requirements
Official installers exist for 64-bit as EXE (NSIS). Installation asks for administrator rights. The installer supports unattended (silent) installation.
Updates and version history
The current version is 53.1, released on March 4, 2026. 4 versions are listed since September 22, 2024, each with links to its own installer files. That is about 2.8 releases a year.
Popularity and file types
The source code on GitHub (ugeneunipro/ugene) has 284 stars. On Windows it registers 56 file types, including .txt, .diff, .pfm, .vcf and .fas. Similar programs include Stellarium, KiCad and Quarto.
Project description on GitHub: “UGENE is free open-source cross-platform bioinformatics software”
Pros / Cons
Pros
- Open source: the code can be inspected and built by anyone
- Documented silent install
- Opens 56 file types
Cons
- No native ARM64 build
- Installation needs administrator rights
In short: UGENE is an open-source science & math tool for 64-bit PCs. Administrators can deploy it unattended.
Is UGENE safe to download?
- The file is served by github.com, the publisher’s own domain
- The download link uses HTTPS
- A SHA256 hash is published, so you can verify the file:
34A81D4C3C0EBDFF0E1FB55AF4A9891EAE55A77E910EDE0524E31A09B759FE09· Open the VirusTotal report for this hash - The link has not been checked yet
- The source code is public
- ExeAtlas does not host, wrap or modify installers
Related guide: How to check a file’s SHA256 hash on Windows
Recent versions
All 4 versions ›4 versions over 1 year · about 2.8 a year
| Version | Date | Size | Files |
|---|---|---|---|
| 53.1Latest | March 4, 2026 | — | 64-bit EXE (NSIS) |
| 52.1 | May 8, 2025 | — | 64-bit EXE (NSIS) |
| 52.0 | January 24, 2025 | — | 64-bit EXE (NSIS) |
| 51.0 | September 22, 2024 | — | 64-bit EXE (NSIS) |
Install from the command line
Silent install ›winget install --id Unipro.UGENE -escoop install extras/ugeneugene-53.1-win-x86-64.exe /SRelated guide: How to use winget: install and update apps
Also for other systems
brew install --cask unipro-ugeneInformation
- Publisher
- Unipro
- Category
- Science & maths
- Licence
- GPL-2.0
- Price
- Free
- Source code
- github.com/ugeneunipro/ugene
- Written in
- C++
- Requires
- Windows 11 / 10
- Architecture
- 64-bit
- Installer
- EXE (NSIS)
- Version
- 53.1
- Released
- March 4, 2026
- Added to the catalogue
- December 9, 2024
- Versions listed
- 4
- Updates / year
- 2.8
- GitHub stars
- 284
- GitHub forks
- 71
- Website
- ugene.net
- winget ID
- Unipro.UGENE
- Scoop package
- extras/ugene
File types it opens (56)
Ratings and reviews
No reviews yet. Be the first to rate it.
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Frequently asked questions
Is UGENE free?
Yes. UGENE is open-source software under the GPL-2.0 licence.
Is UGENE safe to download?
The download comes from github.com, which belongs to the publisher; ExeAtlas does not host or change the file. Compare its SHA256 hash with the one shown here, or open the VirusTotal report for that hash.
How do I install UGENE with winget?
Open PowerShell or Windows Terminal and run the winget command shown on this page. winget downloads the official installer and checks its SHA256 hash before running it.
Can UGENE be installed silently?
Yes. The silent install page lists the exact command for each installer.
Does UGENE run on ARM (Windows on Arm)?
There is no ARM64 build; Windows 11 on Arm can run the 64-bit version through emulation.
Where can I download an older version of UGENE?
The versions page lists all 4 versions with links to their official installer files, back to September 22, 2024.
What are alternatives to UGENE?
Stellarium, KiCad, Quarto, Qalculate! and JASP. The alternatives page compares them.
