SIRIUS is a Java-based software framework for the analysis of LC-MS/MS data of metabolites and other small molecules of biological interest. It integrates a collection of tools, including CSI:FingerID (with COSMIC), ZODIAC and CANOPUS. Both the graphical user interface and the command line version seamlessly integrate the CSI:FingerID, CANOPUS and MSNovelist web services, and the packaged Windows version includes the Java Runtime Environment.
Publisher’s description
What is SIRIUS?
SIRIUS by SIRIUS is open-source Windows software.
Installation and requirements
The publisher provides MSI installers for 64-bit Windows. Installation asks for administrator rights. A silent install is possible with the installer’s documented switches. An MSI package is available for deployment with Group Policy, Intune or Configuration Manager.
Updates and version history
The current version is 6.5.4, released on August 25, 2026. The version history goes back to July 29, 2026: 2 releases, all linked to the official files.
Pros / Cons
Pros
- Open source: the code can be inspected and built by anyone
- MSI package for managed deployment
- Documented silent install
Cons
- No native ARM64 build
- Installation needs administrator rights
In short: SIRIUS is an open-source Windows tool for 64-bit PCs. Administrators can deploy it unattended.
Is SIRIUS safe to download?
- The file is served by github.com, the publisher’s own domain
- The download link uses HTTPS
- A SHA256 hash is published, so you can verify the file:
0254AD8FDDC51196DD78E94C894C13158D328EB7C22C2047D14FB76209BED590· Open the VirusTotal report for this hash - The link has not been checked yet
- The source code is public
- ExeAtlas does not host, wrap or modify installers
Related guide: How to check a file’s SHA256 hash on Windows
Recent versions
All 2 versions ›| Version | Date | Size | Files |
|---|---|---|---|
| 6.5.4Latest | August 25, 2026 | — | 64-bit MSI |
| 6.3.12 | July 29, 2026 | — | 64-bit MSI |
Install from the command line
Silent install ›winget install --id SiriusMS.SIRIUS -emsiexec /i sirius-6.5.4-win-x64.msi /qn /norestartmsiexec /x {6F280E25-28C9-3329-9DD5-53B88EE26C99} /qn /norestartProgram files (.exe): sirius.exe
Related guide: How to use winget: install and update apps
Information
- Publisher
- SIRIUS
- Licence
- AGPL-3.0
- Price
- Free
- Requires
- Windows 11 / 10
- Architecture
- 64-bit
- Installer
- MSI
- Version
- 6.5.4
- Released
- August 25, 2026
- Added to the catalogue
- October 8, 2026
- Versions listed
- 2
- Website
- github.com
- winget ID
- SiriusMS.SIRIUS
- MSI product code
- {6F280E25-28C9-3329-9DD5-53B88EE26C99}
Ratings and reviews
No reviews yet. Be the first to rate it.
Frequently asked questions
Is SIRIUS free?
Yes. SIRIUS is open-source software under the AGPL-3.0 licence.
Is SIRIUS safe to download?
The download comes from github.com, which belongs to the publisher; ExeAtlas does not host or change the file. Compare its SHA256 hash with the one shown here, or open the VirusTotal report for that hash.
How do I install SIRIUS with winget?
Open PowerShell or Windows Terminal and run the winget command shown on this page. winget downloads the official installer and checks its SHA256 hash before running it.
Can SIRIUS be installed silently?
Yes. The silent install page lists the exact command for each installer, including msiexec for the MSI package.
Does SIRIUS run on ARM (Windows on Arm)?
There is no ARM64 build; Windows 11 on Arm can run the 64-bit version through emulation.
Where can I download an older version of SIRIUS?
The versions page lists all 2 versions with links to their official installer files, back to July 29, 2026.