Genome sequencing is generating vast amounts of DNA sequence data from a wide range of organisms. As a result, gene sequence databases are growing rapidly. In order to conduct efficient analyses of these data, there is a need for easy-to-use computer programs, containing fast computational algorithms and useful statistical methods. The objective of the MEGA software has been to provide tools for exploring, discovering, and analyzing DNA and protein sequences from an evolutionary perspective.
Publisher’s description
What is MEGA12?
MEGA12 is a proprietary program for Windows from iGEM.
Installation and requirements
Official installers exist for 64-bit and 32-bit as EXE (Inno Setup). The main installer is 203.0 MB. Installation asks for administrator rights. The installer supports unattended (silent) installation.
Updates and version history
The current version is 12.1.4, released on October 23, 2026. 7 versions are listed since April 9, 2025, each with links to its own installer files. That is about 4.5 releases a year. The last update is less than a month old.
Popularity and file types
On Windows it registers 12 file types, including .mts, .fas, .fasta, .fsa and .meg.
Pros / Cons
Pros
- Documented silent install
- Updated in the last two months
Cons
- Proprietary licence: check the terms and price
- No native ARM64 build
- Installation needs administrator rights
In short: MEGA12 is a Windows tool for 64-bit and 32-bit PCs. It is actively maintained. Administrators can deploy it unattended.
Is MEGA12 safe to download?
- The file is served by megasoftware.net, the publisher’s own domain
- The download link uses HTTPS
- A SHA256 hash is published, so you can verify the file:
F53251FB06578DA0D5EC14EFA3452F144B06460A35E0157483809194635C858A· Open the VirusTotal report for this hash - The link answered when we last checked it (October 26, 2026)
- ExeAtlas does not host, wrap or modify installers
Related guide: How to check a file’s SHA256 hash on Windows
Recent versions
All 7 versions ›7 versions over 2 years · about 4.5 a year
| Version | Date | Size | Files |
|---|---|---|---|
| 12.1.4Latest | October 23, 2026 | 215.1 MB | 64-bit EXE (Inno Setup)32-bit EXE (Inno Setup) |
| 12.1.3 | October 2, 2026 | 215.1 MB | 64-bit EXE (Inno Setup)32-bit EXE (Inno Setup) |
| 12.1.2 | December 16, 2025 | — | 64-bit EXE (Inno Setup)32-bit EXE (Inno Setup) |
| 12.1.1 | November 22, 2025 | — | 64-bit EXE (Inno Setup)32-bit EXE (Inno Setup) |
| 12.0.15 | October 24, 2025 | — | 32-bit EXE (Inno Setup)64-bit EXE (Inno Setup) |
| 12.0.14 | August 20, 2025 | — | 32-bit EXE (Inno Setup)64-bit EXE (Inno Setup) |
| 12.0.11 | April 9, 2025 | — | 32-bit EXE (Inno Setup)64-bit EXE (Inno Setup) |
Install from the command line
Silent install ›winget install --id iGEM.MEGA.12 -eMEGA_12.1.4_win64_setup.exe /VERYSILENT /SUPPRESSMSGBOXES /NORESTART /SP-Related guide: How to use winget: install and update apps
Information
- Publisher
- iGEM
- Licence
- Proprietary
- Price
- See the publisher’s site
- Requires
- Windows 11 / 10
- Architecture
- 64-bit, 32-bit
- Installer
- EXE (Inno Setup)
- Version
- 12.1.4
- Released
- October 23, 2026
- Added to the catalogue
- July 10, 2025
- Versions listed
- 7
- Updates / year
- 4.5
- Website
- megasoftware.net
- winget ID
- iGEM.MEGA.12
File types it opens (12)
Ratings and reviews
No reviews yet. Be the first to rate it.
Frequently asked questions
Is MEGA12 free?
MEGA12 is proprietary (closed-source) software (licence: Proprietary). Whether it costs money depends on the edition: check the publisher’s site for prices and free tiers.
Is MEGA12 safe to download?
The download comes from megasoftware.net, which belongs to the publisher; ExeAtlas does not host or change the file. Compare its SHA256 hash with the one shown here, or open the VirusTotal report for that hash.
How do I install MEGA12 with winget?
Open PowerShell or Windows Terminal and run the winget command shown on this page. winget downloads the official installer and checks its SHA256 hash before running it.
Can MEGA12 be installed silently?
Yes. The silent install page lists the exact command for each installer.
Does MEGA12 run on ARM (Windows on Arm)?
There is no ARM64 build; Windows 11 on Arm can run the 64-bit and 32-bit version through emulation.
Where can I download an older version of MEGA12?
The versions page lists all 7 versions with links to their official installer files, back to April 9, 2025.