API usage of JChem Base in .NET & MarvinSketch and MarvinView with GUI support in .NET.
Publisher’s description
What is JChem .NET API?
JChem .NET API by ChemAxon is proprietary Windows software in the languages & sdks category.
Installation and requirements
The publisher provides MSI installers for 32-bit Windows. The main installer is 334.0 MB. Installation asks for administrator rights. A silent install is possible with the installer’s documented switches. An MSI package is available for deployment with Group Policy, Intune or Configuration Manager.
Updates and version history
The current version is 25.3.4, released on December 15, 2025. The version history goes back to May 22, 2021: 8 releases, all linked to the official files. That is about 1.8 releases a year.
Pros / Cons
Pros
- MSI package for managed deployment
- Documented silent install
Cons
- Proprietary licence: check the terms and price
- No native ARM64 build
- 32-bit only
- Installation needs administrator rights
- Large download (334.0 MB)
In short: JChem .NET API is a languages & sdk tool for 32-bit PCs. Administrators can deploy it unattended.
Is JChem .NET API safe to download?
- The file is served by dl.chemaxon.com, the publisher’s own domain
- The download link uses HTTPS
- A SHA256 hash is published, so you can verify the file:
6DE04F497CAD0D743808ED573B639396198C9A3BE7D466B951895F65EFE7FA46· Open the VirusTotal report for this hash - The link answered when we last checked it (October 22, 2026)
- ExeAtlas does not host, wrap or modify installers
Related guide: How to check a file’s SHA256 hash on Windows
Recent versions
All 8 versions ›8 versions over 5 years · about 1.8 a year
| Version | Date | Size | Files |
|---|---|---|---|
| 25.3.4Latest | December 15, 2025 | 334.0 MB | 32-bit MSI |
| 25.3.2 | September 1, 2025 | — | 32-bit MSI |
| 21.15.2.9 | September 13, 2022 | — | 64-bit MSI |
| 21.15.0.23 | November 10, 2021 | — | 64-bit MSI |
| 21.13.0.593 | August 16, 2021 | — | 64-bit MSI |
| 21.11.0 | July 4, 2021 | — | 64-bit MSI |
| 21.10.0 | June 13, 2021 | — | 64-bit MSI |
| 21.8.0 | May 22, 2021 | — | 64-bit MSI |
Install from the command line
Silent install ›winget install --id ChemAxon.jchemdotnetapi -emsiexec /i ChemAxon_NET_API_25.3.4.msi /qn /norestartmsiexec /x {B14458C0-66E6-415E-BEC8-1BC2CAC954CB} /qn /norestartRelated guide: How to use winget: install and update apps
Information
- Publisher
- ChemAxon
- Category
- Languages & SDKs
- Licence
- Copyright (c) Chemaxon
- Price
- See the publisher’s site
- Requires
- Windows 11 / 10
- Architecture
- 32-bit
- Installer
- MSI
- Version
- 25.3.4
- Released
- December 15, 2025
- Added to the catalogue
- May 22, 2021
- Versions listed
- 8
- Updates / year
- 1.8
- Website
- chemaxon.com
- winget ID
- ChemAxon.jchemdotnetapi
- MSI product code
- {b14458c0-66e6-415e-bec8-1bc2cac954cb}
Ratings and reviews
No reviews yet. Be the first to rate it.
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Frequently asked questions
Is JChem .NET API free?
JChem .NET API is proprietary (closed-source) software (licence: Copyright (c) Chemaxon). Whether it costs money depends on the edition: check the publisher’s site for prices and free tiers.
Is JChem .NET API safe to download?
The download comes from dl.chemaxon.com, which belongs to the publisher; ExeAtlas does not host or change the file. Compare its SHA256 hash with the one shown here, or open the VirusTotal report for that hash.
How do I install JChem .NET API with winget?
Open PowerShell or Windows Terminal and run the winget command shown on this page. winget downloads the official installer and checks its SHA256 hash before running it.
Can JChem .NET API be installed silently?
Yes. The silent install page lists the exact command for each installer, including msiexec for the MSI package.
Does JChem .NET API run on ARM (Windows on Arm)?
There is no ARM64 build; Windows 11 on Arm can run the 32-bit version through emulation.
Where can I download an older version of JChem .NET API?
The versions page lists all 8 versions with links to their official installer files, back to May 22, 2021.
What are alternatives to JChem .NET API?
Go Programming Language, LLVM, Deno, CMake and Yarn. The alternatives page compares them.
